SPRO Spero Therapeutics, Inc. logo

SPRO Spero Therapeutics, Inc.

Healthcare
$2.76+2.60%ClosedMarket Cap: $159.8M

As of 2026-05-25

Valuation

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P/E (TTM)

18.03

PEG

0.16

P/B

2.99

P/S

2.92

EV/EBITDA

7.52

DCF Value

$-30.48

FCF Yield

4.5%

Div Yield

0.0%

Margins & Returns

Gross Margin

100.0%

Operating Margin

24.7%

Net Margin

27.8%

ROE

35.6%

ROA

25.8%

ROIC

23.9%

Financials

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PeriodRevenueNet IncomeEPS
Q1 null$258.0K$-7.2M$
Q4 null$39.7M$31.5M$
FY null$59.6M$8.6M$
Q3 null$3.0M$-7.4M$

Analyst Ratings

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Consensus

Hold

Target (Consensus)

$—

Target (Median)

$—

Target Range

$— - $—

0 Strong Buy0 Buy1 Hold0 Sell0 Strong Sell

Trading Activity

Insider Trades

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Rajavelu Estherofficer: See Remarks
SellWed May 06
Rajavelu Estherofficer: See Remarks
SellMon Feb 09
Rajavelu Estherofficer: See Remarks
SellMon Feb 09
Keutzer Timothyofficer: Chief Operating Officer
SellMon Feb 09
Keutzer Timothyofficer: Chief Operating Officer
SellThu Feb 05

Company Info

Sector

Healthcare

Industry

Biotechnology

Country

US

Exchange

Beta

1.43

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying, developing, and commercializing treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adults; SPR206, a direct acting IV-administered agent to treat MDR Gram-negative bacterial infections in the hospital; and SPR720, an oral antibiotic for the treatment of non-tuberculous mycobacterial pulmonary disease. It has license agreement with Meiji Seika Pharma Co., Ltd. to support the development of tebipenem HBr; license agreement with Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries; collaboration agreement with Bill & Melinda Gates Medical Research Institute to develop SPR720 for the treatment of lung infections caused by Mycobacterium tuberculosis; and license agreement with Vertex Pharmaceuticals Incorporated for patents relating to SPR720, as well as SPR719, an active metabolite. The company was founded in 2013 and is headquartered in Cambridge, Massachusetts.

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