PTGX Protagonist Therapeutics, Inc. logo

PTGX Protagonist Therapeutics, Inc.

Healthcare
$99.19-2.76%ClosedMarket Cap: $6.38B

As of 2026-05-25

Valuation

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P/E (TTM)

PEG

P/B

9.85

P/S

86.13

EV/EBITDA

-46.25

DCF Value

$-9.51

FCF Yield

-1.8%

Div Yield

0.0%

Margins & Returns

Gross Margin

99.5%

Operating Margin

-192.4%

Net Margin

-154.9%

ROE

-17.8%

ROA

-16.4%

ROIC

-21.3%

Financials

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PeriodRevenueNet IncomeEPS
Q1 null$56.4M$3.8M$
Q4 null$7.4M$-44.4M$
FY null$46.0M$-130.1M$
Q3 null$4.7M$-39.3M$

Analyst Ratings

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Consensus

Buy

Target (Consensus)

$115.40

Target (Median)

$117.00

Target Range

$108.00 - $121.00

3 Strong Buy9 Buy1 Hold0 Sell0 Strong Sell
WedbushOutperform
2026-05-06
CitizensMarket Outperform
2026-05-06
Truist SecuritiesBuy
2026-04-15
Clear StreetBuy
2026-04-07
Leerink PartnersOutperform
2026-03-19

Trading Activity

Insider Trades

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PATEL DINESH V PH Ddirector, officer: President and CEO
SellTue May 12
PATEL DINESH V PH Ddirector, officer: President and CEO
SellTue May 12
Giraudo Bryandirector
SellMon May 11
Giraudo Bryandirector
SellMon May 11
Giraudo Bryandirector
SellMon May 11

Company Info

Sector

Healthcare

Industry

Biotechnology

Country

US

Exchange

Beta

1.88

Protagonist Therapeutics, Inc., a biopharmaceutical company, discovers and develops peptide-based therapeutic drugs to address hematology and blood disorders, and inflammatory and immunomodulatory diseases. It is developing rusfertide (PTG-300), an injectable hepcidin mimetic that is in Phase II clinical trials for the treatment of patients with polycythemia vera and hereditary hemochromatosis, as well as for the treatment of other blood disorders; PN-943, an oral, alpha-4-beta-7 integrin- specific antagonist peptide that is in Phase II clinical trials for treating inflammatory bowel disease (IBD); and PN-235, an orally delivered interleukin-23 receptor specific antagonist for the treatment of IBD and non-IBD indications. The company has a license and collaboration agreement with Janssen Biotech, Inc. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

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