Nuvation Bio is upgraded to Buy, driven by Ibtrozi's growing adoption in ROS1+ NSCLC and improved modeling assumptions. Ibtrozi's median response duration approaches 50 months, with first-line patient share now exceeding 50%, supporting significant revenue stacking. Revised SOTP analysis values NUVB equity at $2.1 billion ($6.03/share), about 25% above current prices.